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Disease-associated mutations prevent GPR56-collagen III interaction.

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GPR56 is a member of the adhesion G protein-coupled receptor (GPCR) family. Mutations in GPR56 cause a devastating human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Using the N-terminal fragment of GPR56 (GPR56(N)) as a probe. we have recently demonstrated that collagen III is the ligand of GPR56 in the developing brain. https://foldlyers.shop/product-category/coaxial-tv-cables/
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