A massive periodontal destruction can affect the root canal (RC) system and potentially expose the pulpo-dentinal complex to opportunistic bacteria. Streptococcus mutans is a major pathogen of human caries and periodontal diseases. and its virulence mostly resides in the ability to adhere to collagen and form biofilms. due to collagen-binding proteins (CBPs) Cnm and Cbm. https://missouriquiltcoes.shop/product-category/hand-sewing-needles/